About the ACMG Evidence-Based Guidelines Program
The Evidence Based Guidelines (EBG) Program is an important joint effort between the ACMG
Foundation and ACMG. The EBG Program develops unbiased guidelines in medical genetics and
genomics and provides a solid evidence base to demonstrate the clinical utility of genetic or genomic
services. ACMG’s guidelines help clinicians make informed decisions regarding the use of genetic and
genomic testing and aid both government and private health insurers in determining coverage options
for new tests and treatments.
The ACMG Foundation is working to build support for this critical program. With your help, ACMG will
develop, publish, and regularly update evidence-based guidelines. The support of individuals,
foundations, and corporate donors will ensure that ACMG can disseminate guidelines more often and
more quickly, now and in the future.
The documents linked below detail the need for ACMG’s EBG Program and explain the program’s
management, operations, and funding goals. The materials included on this page also detail next steps,
the expectations of the ACMG Board, and the role of our members.
Background on the EBG Program
- Please click here to read the one-page overview of the EBG Program. This is perhaps the best
entry point to the effort.
- For those who wish to learn more about ACMG’s Evidence Based Guideline Program please
review the “Four Year Launch Plan,” which details ACMG’s goals and the role of the ACMGF.
This document also details ACMG’s long tradition as an organization and our prior
accomplishments with Guideline Development.
- The Topic Selection Committee is responsible for moving new topics into the EBG Program’s
development pipeline. Click this link to read the most recent overview of the Topic Selection
- In addition, Q & A with Dr. Laurie Demmer, Chair of the Topic Selection
Committee for ACMG’s New Evidence-Based Guidelines Program can be found here.
- A press release announcing the launch of the EBG Program can be found here.
- The Topic Selection Committee’s Topic Nomination Form is the mechanism that healthcare
professionals may use to submit feedback and guideline topic ideas to the ACMG for further
consideration. To submit a possible topic to the Committee, please click here.
- The Members of the Topic Selection Committee are published here.
- In 2014, the ACMG Board and staff developed the PROTOCOL MANUAL for EVIDENCE-BASED
GUIDELINES that would guide the ACMG Board and committee members in development of
evidence based guidelines. You may find the manual here.
- The development of each new guideline will demand a tremendous investment of staff time at
every level of the organization. Two areas will be crucial for the successful management of this
- A dedicated EBG Fund for donations from all sources that includes a firewall between
the fundraising teams on the side of the ACMG Foundation and the scientific teams
working under the banner of the ACMG. Documents that outline THE ACMG
Foundation’s “Guidelines Fund” can be found here.
- A carefully managed budget will ensure that resources raised for this effort will be
directed towards the proper resources to ensure a successful effort each time a new
guideline is published. To review some sample budgets that the ACMG Foundation
drafted as goals for both the overall program and for fundraising targets, please click
For questions related to the Evidence Based Guidelines Program, please contact the ACMG Foundation